Characterization of growth hormone binding sites in rat brain.

  title={Characterization of growth hormone binding sites in rat brain.},
  author={Qingzhu Zhai and Zefeng Lai and Paul Roos and Fred J Nyberg},
  journal={Acta paediatrica (Oslo, Norway : 1992). Supplement},
The binding of 125I-labelled rat growth hormone (GH) to different areas in the brain was studied in male Sprague-Dawley rats. A high density of GH binding was found in the choroid plexus, hypothalamus, hippocampus, pituitary and spinal cord, whereas a lower binding density was observed in the cortex. Binding of the hormone to the various brain regions was age dependent. Binding was also dependent on time, pH and protein concentration. The binding affinity of the labelled hormone to choroid… CONTINUE READING