Characterization of glycosaminoglycans by 15N NMR spectroscopy and in vivo isotopic labeling.

@article{Pomin2010CharacterizationOG,
  title={Characterization of glycosaminoglycans by 15N NMR spectroscopy and in vivo isotopic labeling.},
  author={Vitor H Pomin and Joshua S Sharp and Xuanyang Li and Lianchun Wang and James H. Prestegard},
  journal={Analytical chemistry},
  year={2010},
  volume={82 10},
  pages={
          4078-88
        }
}
Characterization of glycosaminoglycans (GAGs), including chondroitin sulfate (CS), dermatan sulfate (DS), and heparan sulfate (HS), is important in developing an understanding of cellular function and in assuring quality of preparations destined for biomedical applications. While use of (1)H and (13)C NMR spectroscopy has become common in characterization of these materials, spectra are complex and difficult to interpret when a more heterogeneous GAG type or a mixture of several types is… CONTINUE READING
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