• Published 2011

Characterization of glucose-insulin responsiveness and impact of fetal number and gender 1 on insulin response in the sheep fetus 2 3

@inproceedings{Green2011CharacterizationOG,
  title={Characterization of glucose-insulin responsiveness and impact of fetal number and gender 1 on insulin response in the sheep fetus 2 3},
  author={Alice S. Green and Antoni R. Macko and Paul J Rozance and Dustin T. Yates and Xiaochuan Chen and William W Jr. Hay and Sean W Limesand},
  year={2011}
}
21 Glucose stimulated insulin secretion (GSIS) is often measured in the sheep fetus by a square22 wave hyperglycemic clamp, but maximal β-cell responsiveness and effects of fetal number and 23 gender have not been fully evaluated. We determined the dose-response curve for GSIS in fetal 24 sheep (0.9 of gestation) by increasing plasma glucose from euglycemia in a stepwise fashion. 25 The glucose-insulin response was best fit by curvilinear third-order polynomial equations for 26 singletons (y=0… CONTINUE READING

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