Characterization of glucagon-like peptide-1 receptor-binding determinants.

@article{Xiao2000CharacterizationOG,
  title={Characterization of glucagon-like peptide-1 receptor-binding determinants.},
  author={Q Xiao and Wong Chow Jeng and Margaret B Wheeler},
  journal={Journal of molecular endocrinology},
  year={2000},
  volume={25 3},
  pages={
          321-35
        }
}
Glucagon-like peptide 1 (GLP-1) is a potent insulinotropic hormone currently under study as a therapeutic agent for type 2 diabetes. Since an understanding of the molecular mechanisms leading to high-affinity receptor (R) binding and activation may facilitate the development of more potent GLP-1R agonists, we have localized specific regions of GLP-1R required for binding. The purified N-terminal fragment (hereafter referred to as NT) of the GLP-1R produced in either insect (Sf9) or mammalian… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

VIEW 23 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Dimerization/oligomerization of the extracellular domain of the GLP-1 receptor and the negative cooperativity in its ligand binding revealed by the improved NanoBiT.

VIEW 10 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS
HIGHLY INFLUENCED

Molecular evolution of GPCRs: GLP1/GLP1 receptors.

VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Exploring the Structure, Function & Regulation of the Human Glucagon-Like Peptide-1 Receptor

VIEW 4 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

The production of nonpeptidyl growth hormone secretagogue. www.merck.com/mrl/speakerlist/ MRL speakers program

  • RJ DeVita
  • 2000
VIEW 2 EXCERPTS