Characterization of global transcription profile of normal and HPV-immortalized keratinocytes and their response to TNF treatment

@article{Termini2008CharacterizationOG,
  title={Characterization of global transcription profile of normal and HPV-immortalized keratinocytes and their response to TNF treatment},
  author={Lara Termini and Enrique Boccardo and Gustavo H. Esteves and Roberto Hirata and Waleska Kerllen Martins and Anna Estela L Colo and Eduardo Jord{\~a}o Neves and Luisa L. Villa and Luiz F. L. Reis},
  journal={BMC Medical Genomics},
  year={2008},
  volume={1},
  pages={29 - 29}
}
Persistent infection by high risk HPV types (e.g. HPV-16, -18, -31, and -45) is the main risk factor for development of cervical intraepithelial neoplasia and cervical cancer. Tumor necrosis factor (TNF) is a key mediator of epithelial cell inflammatory response and exerts a potent cytostatic effect on normal or HPV16, but not on HPV18 immortalized keratinocytes. Moreover, several cervical carcinoma-derived cell lines are resistant to TNF anti-proliferative effect suggesting that the… CONTINUE READING
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Immune responses to human papillomavirus

  • M Stanley
  • Vaccine
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