Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.

@article{Frisn1993CharacterizationOG,
  title={Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.},
  author={Jonas Fris{\'e}n and Valerie M. K. Verge and Kaj Fried and M{\aa}rten Risling and H{\aa}kan Persson and Jacqueline Trotter and Tomas G M H{\"o}kfelt and Dan Lindholm},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 11},
  pages={4971-5}
}
In situ hybridization on sections from the adult rat peripheral and central nervous systems demonstrated that trkB mRNA was expressed not only by neurons but also by cells in central nervous system white matter as well as by Schwann cells in the sciatic nerve. In situ hybridization with an oligonucleotide complementary to the trkB tyrosine kinase domain could only demonstrate mRNA in neurons, indicating expression of truncated trkB receptors lacking the tyrosine kinase domain by glial cells… CONTINUE READING