Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization

@article{Chepelev2012CharacterizationOG,
  title={Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization},
  author={Iouri Chepelev and Gang W. Wei and Dara Wangsa and Qingsong Tang and Keji Zhao},
  journal={Cell Research},
  year={2012},
  volume={22},
  pages={490-503}
}
Recent epigenomic studies have predicted thousands of potential enhancers in the human genome. However, there has not been systematic characterization of target promoters for these potential enhancers. Using H3K4me2 as a mark for active enhancers, we identified genome-wide EP interactions in human CD4+ T cells. Among the 6 520 long-distance chromatin interactions, we identify 2 067 enhancers that interact with 1 619 promoters and enhance their expression. These enhancers exist in accessible… CONTINUE READING
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