Characterization of gamma2-human herpesvirus-8 glycoproteins gH and gL.

  title={Characterization of gamma2-human herpesvirus-8 glycoproteins gH and gL.},
  author={Pramod P. Naranatt and Shaw M Akula and B. Poornima Chandran},
  journal={Archives of virology},
  volume={147 7},
The gamma2 human herpesvirus-8 (HHV-8) or Kaposi's sarcoma associated herpesvirus (KSHV) ORFs 22 and 47 are counterparts to glycoproteins gH and gL, respectively, that are conserved among the members of herpesviruses. To define HHV-8 gH and gL, rabbit polyclonal antibodies were raised against GST-gH and GST-gL fusion proteins. Anti-gL and anti-gH antibodies reacted with the surface of virus carrying BCBL-1 cells. Both antibodies immunoprecipitated the HHV-8 envelope associated 120 kDa and 41-42… CONTINUE READING