Characterization of functional chemokine receptors (CCR1 and CCR2) on EoL-3 cells: a model system to examine the role of chemokines in cell function.

@article{Sarau1997CharacterizationOF,
  title={Characterization of functional chemokine receptors (CCR1 and CCR2) on EoL-3 cells: a model system to examine the role of chemokines in cell function.},
  author={Henry M. Sarau and Julia A. Rush and James J. Foley and Mary E. Brawner and Dulcie B. Schmidt and John R. White and Mary S. Barnette},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 1},
  pages={411-8}
}
A growing family of proteins, known as the chemokines, play an important role in the recruitment and activation of inflammatory cells. The purpose of these studies was to characterize the chemokine receptors present on human sodium butyrate differentiated EoL-3 cells (dEoL-3 cells). Using a combination of 3' rapid amplification of cDNA ends and nested polymerase chain reaction, we detected mRNA for CC chemokine receptor (CCR)1, CCR2, CCR3 and low level of CCR5. Radioligand binding studies… CONTINUE READING

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