Characterization of four substrates emphasizes kinetic similarity between insect and human C-domain angiotensin-converting enzyme.

Abstract

Angiotensin converting enzyme (ACE) was already discovered in insects in 1994, but its physiological role is still enigmatic. We have addressed this problem by purifying four new ACE substrates from the ovaries of the grey fleshfly, Neobellieria bullata. Their primary structures were identified as NKLKPSQWISLSD (Neb-ODAIF-1(1-13)), NKLKPSQWI (Neb-ODAIF-1(1… (More)

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@article{Hens2002CharacterizationOF, title={Characterization of four substrates emphasizes kinetic similarity between insect and human C-domain angiotensin-converting enzyme.}, author={Korneel Hens and Anick Vandingenen and Nathalie Macours and Geert Baggerman and Adriana Carmona Karaoglanovic and Liliane Schoofs and Arnold De Loof and Roger Huybrechts}, journal={European journal of biochemistry}, year={2002}, volume={269 14}, pages={3522-30} }