Characterization of four different effects elicited by H2O2 in rat aorta.

@article{GilLongo2005CharacterizationOF,
  title={Characterization of four different effects elicited by H2O2 in rat aorta.},
  author={Jos{\'e} Gil-Longo and Cristina Gonz{\'a}lez-V{\'a}zquez},
  journal={Vascular pharmacology},
  year={2005},
  volume={43 2},
  pages={128-38}
}
Four main vascular effects of hydrogen peroxide (H2O2) were studied in intact and rubbed aortic rings from WKY rats. In rings partially precontracted with phenylephrine: 1-30 microM H2O2 induced an increase of tone, 100 microM H2O2 produced a transient contraction followed by a fast-developing endothelium-independent relaxation, and 0.3 mM H2O2 induced a fast-developing relaxation followed by a slow-developing endothelium-independent relaxation. Superoxide dismutase (SOD) or dimethyl sulfoxide… CONTINUE READING

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Four main vascular effects of hydrogen peroxide ( H2O2 ) were studied in intact and rubbed aortic rings from WKY rats .
Superoxide dismutase ( SOD ) or dimethyl sulfoxide ( DMSO)/manitol did not significantly modify the H2O2 effects , while catalase suppressed them .
Superoxide dismutase ( SOD ) or dimethyl sulfoxide ( DMSO)/manitol did not significantly modify the H2O2 effects , while catalase suppressed them .
In summary , H2O2 produces : ( 1 ) contractions mediated by direct activation of cyclooxygenase ; 2 ) endothelium - dependent relaxations related to activation of endothelial K+ channels and NO synthesis ; 3 ) reversible endothelium - independent relaxations mediated by activation of smooth muscle K+ channels ; and 4 ) irreversible endothelium - independent relaxations related to cellular damage , caused by H2O2 but not by hydroxyl radicals .
In summary , H2O2 produces : ( 1 ) contractions mediated by direct activation of cyclooxygenase ; 2 ) endothelium - dependent relaxations related to activation of endothelial K+ channels and NO synthesis ; 3 ) reversible endothelium - independent relaxations mediated by activation of smooth muscle K+ channels ; and 4 ) irreversible endothelium - independent relaxations related to cellular damage , caused by H2O2 but not by hydroxyl radicals .
Four main vascular effects of hydrogen peroxide ( H2O2 ) were studied in intact and rubbed aortic rings from WKY rats .
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