Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95.

@article{Shaw2001CharacterizationOF,
  title={Characterization of four CD18 mutants in leucocyte adhesion deficient (LAD) patients with differential capacities to support expression and function of the CD11/CD18 integrins LFA-1, Mac-1 and p150,95.},
  author={Jonathan M Shaw and Aymen Al-Shamkhani and Laurence Boxer and Christopher D Buckley and Alister W. Dodds and Nigel Klein and S M Nolan and Ian W. Roberts and Dirk Roos and Sylvia Scarth and David Ll. Simmons and Shen Mynn Tan and Simon K. Law},
  journal={Clinical and experimental immunology},
  year={2001},
  volume={126 2},
  pages={311-8}
}
Leucocyte adhesion deficiency (LAD) is a hereditary disorder caused by mutations in the CD18 (beta2 integrin) gene. Four missense mutations have been identified in three patients. CD18(A270V) supports, at a diminished level, CD11b/CD18 (Mac-1, alphaMbeta2 integrin) and CD11c/CD18 (p150,95, alphaXbeta2 integrin) expression and function but not CD11a/CD18 (LFA-1, alphaLbeta2 integrin) expression. Conversely, CD18(A341P) supports a limited level of expression and function of CD11a/CD18, but not of… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
18 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…