Characterization of fluoromisonidazole binding in stroke.

@article{Spratt2006CharacterizationOF,
  title={Characterization of fluoromisonidazole binding in stroke.},
  author={Neil James Spratt and Uwe Ackerman and Henri Jacques Tochon-Danguy and Geoffrey Alan Donnan and David William Howells},
  journal={Stroke},
  year={2006},
  volume={37 7},
  pages={1862-7}
}
BACKGROUND AND PURPOSE [18F]fluoromisonidazole (FMISO) positron emission tomography has been used to image hypoxia early after human stroke. To further study the role of hypoxia in stroke and the binding characteristics of FMISO, we aimed to develop [3H]FMISO autoradiography in an animal stroke model. We hypothesized that [3H]FMISO binding is prolonged, allowing correlation with 24-hour histology, and that there is no FMISO binding after effective reperfusion. METHODS Temporary middle… CONTINUE READING

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Brain hypoxia mapping in acute stroke: Back-to-back T2' MR versus 18F-fluoromisonidazole PET in rodents.

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Imaging of hypoxic-ischemic penumbra with (18)F-fluoromisonidazole PET/CT and measurement of related cerebral metabolism in aneurysmal subarachnoid hemorrhage.

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