Characterization of fibroblast growth factor 1 binding heparan sulfate domain.

  title={Characterization of fibroblast growth factor 1 binding heparan sulfate domain.},
  author={Johan Kreuger and Kristian Prydz and Ralf F. Pettersson and Ulf Lindahl and Markku Salmivirta},
  volume={9 7},
Fibroblast growth factors FGF-1 and FGF-2 mediate their biological effects via heparan sulfate-dependent interactions with cell surface FGF receptors. While the specific heparan sulfate domain binding to FGF-2 has been elucidated in some detail, limited information has been available concerning heparan sulfate structures involved in the recognition of FGF-1. In the current study we present evidence that the minimal FGF-1 binding heparan sulfate sequence comprises 5-7 monosaccharide units and… CONTINUE READING
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