Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural function.

@article{Anitha2008CharacterizationOF,
  title={Characterization of fetal and postnatal enteric neuronal cell lines with improvement in intestinal neural function.},
  author={Mallappa Anitha and Irene Joseph and Xiaokun Ding and Enrique de la Torre and Michael A. Sawchuk and Simon Mwangi and Shawn Hochman and Shanthi V. Sitaraman and Frank A Anania and S. Deepak Srinivasan},
  journal={Gastroenterology},
  year={2008},
  volume={134 5},
  pages={1424-35}
}
BACKGROUND & AIMS The isolation and culture of primary enteric neurons is a difficult process and yields a small number of neurons. We developed fetal and postnatal enteric neuronal cell lines using H-2K(b)-tsA58 transgenic mice (immortomice) that have a temperature-sensitive mutation of the SV40 large tumor antigen gene under the control of an interferon gamma-inducible H-2K(b) promoter element. METHODS Enteric neuronal precursors were isolated from the intestines of E13-mouse fetuses and… CONTINUE READING

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