Characterization of fertilization-blocking monoclonal antibody 1G12 with human sperm-immobilizing activity.


A mouse hybridoma (1G12) producing sperm-immobilizing MoAb to human sperm was established and characterized in order to study the antigens relevant to sperm immobilization by antibodies. MoAb 1G12 had strong sperm-immobilizing and agglutinating activities and also showed a fertilization-blocking activity on in vitro fertilization tests. The antibody… (More)


  • Presentations referencing similar topics