Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils.

@article{Andersson1986CharacterizationOF,
  title={Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils.},
  author={Tommy Andersson and Claes Dahlgren and Tullio Pozzan and Olle Stendahl and Prof. Daniel P. Lew},
  journal={Molecular pharmacology},
  year={1986},
  volume={30 5},
  pages={
          437-43
        }
}
N-Formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe) stimulation of human neutrophils leads to a rapid increase of the cytosolic free Ca2+ concentration, [Ca2+]i, which is significantly reduced by removal of extracellular calcium. In the present study we show that fMet-Leu-Phe-induced [Ca2+]i increases are, in part, mediated by an increase of the plasma membrane permeability to Ca2+. This conclusion is based on the following evidence. In the presence of extracellular calcium, addition… CONTINUE READING

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