Characterization of exogenous bacterial oligosaccharyltransferases in Escherichia coli reveals the potential for O-linked protein glycosylation in Vibrio cholerae and Burkholderia thailandensis.

@article{Gebhart2012CharacterizationOE,
  title={Characterization of exogenous bacterial oligosaccharyltransferases in Escherichia coli reveals the potential for O-linked protein glycosylation in Vibrio cholerae and Burkholderia thailandensis.},
  author={Carol Gebhart and Maria Veronica Ielmini and B{\'e}la Reiz and Nancy L. Price and Finn Erik Aas and Michael Koomey and Mario F Feldman},
  journal={Glycobiology},
  year={2012},
  volume={22 7},
  pages={962-74}
}
Bacterial protein glycosylation systems from varying species have been functionally reconstituted in Escherichia coli. Both N- and O-linked glycosylation pathways, in which the glycans are first assembled onto lipid carriers and subsequently transferred to acceptor proteins by an oligosaccharyltransferase (OTase), have been documented in bacteria. The identification and characterization of novel OTases with different properties may provide new tools for engineering glycoproteins of… CONTINUE READING
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