Characterization of evolutionary rates and constraints in three Mammalian genomes.

  title={Characterization of evolutionary rates and constraints in three Mammalian genomes.},
  author={Gregory M. Cooper and Michael Brudno and Eric A. Stone and Inna Dubchak and Serafim Batzoglou and Arend Sidow},
  journal={Genome research},
  volume={14 4},
We present an analysis of rates and patterns of microevolutionary phenomena that have shaped the human, mouse, and rat genomes since their last common ancestor. We find evidence for a shift in the mutational spectrum between the mouse and rat lineages, with the net effect being a relative increase in GC content in the rat genome. Our estimate for the neutral point substitution rate separating the two rodents is 0.196 substitutions per site, and 0.65 substitutions per site for the tree relating… CONTINUE READING
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Genome sequence of the Brown Norway Rat yields insights into mammalian evolution

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  • Nature (in press).
  • 2004

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