Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists.

@article{Wang1994CharacterizationOE,
  title={Characterization of endothelin-1-induced vascular effects in the rat heart by using endothelin receptor antagonists.},
  author={Qu Dong Wang and X S Li and John Pernow},
  journal={European journal of pharmacology},
  year={1994},
  volume={271 1},
  pages={
          25-30
        }
}
The coronary vasoconstrictor effect of endothelin-1 was characterized in the isolated rat heart by using the endothelin ETA receptor antagonist D-Asp-L-Pro-D-Val-L-Leu-D-Trp (BQ-123) and the endothelin ETB receptor antagonist [Cys11-Cys15]endothelin-1-(11-21) (IRL 1038). In addition, the involvement of nitric oxide and cyclooxygenase products was investigated. Endothelin-1 (0.012-0.4 nmol) dose dependently reduced coronary flow, which reached a maximum reduction of 83% at 0.4 nmol. BQ-123 (1… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 14 CITATIONS

NO and NO-independent mechanisms mediate ETB receptor buffering of ET-1-induced renal vasoconstriction in the rat.

VIEW 4 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

Nitric oxide the gatekeeper of endothelial vasomotor control.

AM reverses pressor response to ET-1 independently of NO in rat coronary circulation.

VIEW 2 EXCERPTS
CITES BACKGROUND