Characterization of endoscopic ultrasound fine-needle aspiration cytology by targeted next-generation sequencing and theranostic potential.

@article{Gleeson2015CharacterizationOE,
  title={Characterization of endoscopic ultrasound fine-needle aspiration cytology by targeted next-generation sequencing and theranostic potential.},
  author={Ferga C. Gleeson and Benjamin R. Kipp and Sarah E. Kerr and Jesse S. Voss and Konstantinos N. Lazaridis and D A Katzka and Michael J. Levy},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  year={2015},
  volume={13 1},
  pages={37-41}
}
Determination of tumor genetic architecture based on tissue analysis yields important information on signaling pathways involved in cancer pathogenesis and plays a growing role in choosing the optimal medical management of malignancies. Specifically, the advent of next-generation sequencing has led to a rapidly evolving era of relatively inexpensive, high-throughput DNA sequencing of tumors. One such example is multiplexed tumor genotyping (ie, panel testing) of more than 2800 mutations across… CONTINUE READING
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