Characterization of endomorphin-1 and -2 on [35S]GTPgammaS binding in the mouse spinal cord.

@article{Narita1998CharacterizationOE,
  title={Characterization of endomorphin-1 and -2 on [35S]GTPgammaS binding in the mouse spinal cord.},
  author={Minoru Narita and Hirokazu Mizoguchi and George S Oji and Elaine Tseng and C Suganuma and Hiroshi Nagase and Leon Fu Tseng},
  journal={European journal of pharmacology},
  year={1998},
  volume={351 3},
  pages={
          383-7
        }
}
In the present study, G-protein activation by newly-isolated opioid peptides, endomorphin-1 and -2, was examined in the mouse spinal cord by monitoring the binding of the non-hydrolyzable analog of GTP, guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS). Both endomorphin-1 and -2 increased [35S]GTPgammaS binding to mouse spinal cord membranes in a concentration-dependent and saturable manner and reached a maximal stimulation of 57.3+/-5.0 and 60.2+/-3.2%, respectively, at 10 microM. In… CONTINUE READING
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