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3 Citations
First report of whole-genome analysis of an extensively drug-resistant Mycobacterium tuberculosis clinical isolate with bedaquiline, linezolid and clofazimine resistance from Uganda
- BiologyAntimicrobial resistance and infection control
- 2022
This is the first identification of extensively drug-resistant Mycobacterium tuberculosis clinical isolates with bedaquiline, linezolid and clofazimine resistance from Uganda, and strongly highlights the importance of combating DR-TB in Africa through implementing next generation sequencing that can test resistance to all drugs while providing a faster turnaround time.
In Silico Approach for Phytocompound-Based Drug Designing to Fight Efflux Pump-Mediated Multidrug-Resistant Mycobacterium tuberculosis
- BiologyApplied Biochemistry and Biotechnology
- 2021
The mechanism and appearance of drug resistance in Mycobacterium tuberculosis with emphasis on efflux pumps along with the significance of phytochemicals as inhibitors of these pumps and their screening strategy by computational approaches are highlighted.
Molecular modelling and simulation studies of the Mycobacterium tuberculosis multidrug efflux pump protein Rv1258c
- BiologyPloS one
- 2018
An accurate 3D model of Rv1258c is generated using MODELLER and its structure is validated using molecular dynamic simulation studies with GROMACS software and Spectinamide was found to bind to a different location on the outside surface of the protein suggesting its ability to avoid the efflux channel.
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