Characterization of early stages in vaccinia virus membrane biogenesis: implications of the 21-kilodalton protein and a newly identified 15-kilodalton envelope protein.

@article{Rodriguez1997CharacterizationOE,
  title={Characterization of early stages in vaccinia virus membrane biogenesis: implications of the 21-kilodalton protein and a newly identified 15-kilodalton envelope protein.},
  author={Jorge Raul Rodriguez and Cristina M Risco and Jos{\'e} L Carrascosa and M Mart{\'i}n Esteban and D Rodr{\'i}guez},
  journal={Journal of virology},
  year={1997},
  volume={71 3},
  pages={1821-33}
}
Vaccinia virus (VV) membrane biogenesis is a poorly understood process. It has been proposed that cellular membranes derived from the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) are incorporated in the early stages of virion assembly. We have recently shown that the VV 21-kDa (A17L gene) envelope protein is essential for the formation of viral membranes. In the present work, we identify a 15-kDa VV membrane protein encoded by the A14L gene. This protein is phosphorylated and… CONTINUE READING

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