Characterization of early host responses in adults with dengue disease

  title={Characterization of early host responses in adults with dengue disease},
  author={Thomas Tolfvenstam and Anna Lindblom and Mark J. Schreiber and L. Ling and Angelia Yee Chow and Eng Eong Ooi and Martin L. Hibberd},
  booktitle={BMC infectious diseases},
BACKGROUND While dengue-elicited early and transient host responses preceding defervescence could shape the disease outcome and reveal mechanisms of the disease pathogenesis, assessment of these responses are difficult as patients rarely seek healthcare during the first days of benign fever and thus data are lacking. METHODS In this study, focusing on early recruitment, we performed whole-blood transcriptional profiling on dengue virus PCR positive patients sampled within 72 h of self… CONTINUE READING
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