Characterization of early EDEM1 protein maturation events and their functional implications.

@article{Tamura2011CharacterizationOE,
  title={Characterization of early EDEM1 protein maturation events and their functional implications.},
  author={Taku Tamura and James H. Cormier and Daniel N Hebert},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 28},
  pages={
          24906-15
        }
}
The endoplasmic reticulum (ER) quality control factor EDEM1 associates with a number of ER proteins and ER-associated degradation (ERAD) substrates; however, an understanding of its role in ERAD is unclear. The early maturation events for EDEM1 including signal sequence cleavage and glycosylation were analyzed, and their relationship to the function of EDEM1 was determined. EDEM1 has five N-linked glycosylation sites with the most C-terminal site recognized poorly cotranslationally, resulting… CONTINUE READING

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Protein quality control, retention, and degradation at the endoplasmic reticulum.

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