Characterization of dp6troglycan-laminin interaction in peripheral nerve.

  title={Characterization of dp6troglycan-laminin interaction in peripheral nerve.},
  author={Hideki Yamada and Ayako Chiba and Takeshi Endo and Akira Kobata and Louise V. B. Anderson and Hiroyuki Hori and Hiroko Fukuta-Ohi and Ichiro Kanazawa and Kevin P Campbell and Teruo Shimizu and Kiichiro Matsumura},
  journal={Journal of neurochemistry},
  volume={66 4},
Dystoroglycan is encoded by a single gene and cleaved into two proteins, alpha and beta-dystroglycan, by posttranslational processing. The 120kDa peripheral nerve isoform of alpha-dystroglycan binds laminin-2 comprised of the alpha 2, beta 1, and gamma 1 chains. In congenital muscular dystrophy and dy mice deficient in laminin alpha 2 chain, peripheral myelination is disturbed, suggesting a role for the dystroglycan- laminin interaction in peripheral myelinogenesis. To begin to test this… CONTINUE READING
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