Characterization of direct antiglobulin test-negative autoimmune hemolytic anemia: a study of 154 cases.

@article{Kamesaki2013CharacterizationOD,
  title={Characterization of direct antiglobulin test-negative autoimmune hemolytic anemia: a study of 154 cases.},
  author={Toyomi Kamesaki and Tomonori Toyotsuji and Eiji Kajii},
  journal={American journal of hematology},
  year={2013},
  volume={88 2},
  pages={93-6}
}
Direct antiglobulin test (DAT)-negative (DAT-)autoimmune hemolytic anemia (AIHA) is empirically thought to show the same clinical conditions as DAT-positive (DAT+)AIHA, with the exception of an adequate amount of red blood cell (RBC)-bound immunoglobulin (Ig)G. We investigated the clinical characteristics of DAT-AIHA in comparison with DAT+AIHA. Of the 582 patients referred to our laboratory with undiagnosed hemolytic anemia, AIHA was clinically diagnosed in 216 patients (DAT-AIHA, n = 154; DAT… CONTINUE READING