Characterization of different molecular forms of 5'-nucleotidase in normal serum and in serum from cholestatic patients and bile-duct-ligated rats.


Serum 5'-nucleotidase in rat and man is derived from the plasma membrane rather than the cytosol by the criteria of inhibition with [alpha beta-methylene]ADP and antisera. In individuals with cholestasis the serum enzyme is mainly present as a high-Mr form that in the presence of the zwitterionic detergent Sulphobetaine 14 has the electrophoretic… (More)


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