Characterization of different CTC subpopulations in non-small cell lung cancer

@inproceedings{Hanssen2016CharacterizationOD,
  title={Characterization of different CTC subpopulations in non-small cell lung cancer},
  author={Annkathrin Hanssen and Jenny Wagner and Tobias M. Gorges and Aline Taenzer and Faik G{\"u}ntac Uzunoglu and Christiane Driemel and Nikolas H Stoecklein and Wolfram Trudo Knoefel and Sebastian Angenendt and Siegfried Hauch and Djordje Atanackovic and Sonja Loges and Sabine Riethdorf and Klaus Pantel and Harriet Wikman},
  booktitle={Scientific reports},
  year={2016}
}
Circulating tumour cells (CTCs) serve as valuable biomarkers. However, EpCAM positive CTCs are less frequently detected in NSCLC patients compared to other epithelial tumours. First, EpCAM protein expression was analysed in primary and metastatic lung cancer tissue. In both groups 21% of the samples were EpCAM negative. Second, the CellSearch system identified 15% of patients (n = 48) as CTC positive whereas a multiplex RT-PCR for PIK3CA, AKT2, TWIST, and ALDH1 following EGFR, HER2 and EpCAM… CONTINUE READING
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