Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins.

@article{Parkin1999CharacterizationOD,
  title={Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins.},
  author={Edward T. Parkin and Ishrut Hussain and Eric H. Karran and Anthony J. Turner and Nigel M Hooper},
  journal={Journal of neurochemistry},
  year={1999},
  volume={72 4},
  pages={1534-43}
}
Many cases of early-onset familial Alzheimer's disease have been linked to mutations within two genes encoding the proteins presenilin-1 and presenilin-2. The presenilins are 48-56-kDa proteins that can be proteolytically cleaved to generate an N-terminal fragment (approximately 25-35 kDa) and a C-terminal fragment (approximately 17-20 kDa). The N- and C-terminal fragments of presenilin-1, but not full-length presenilin-1, were readily detected in both human and mouse cerebral cortex and in… CONTINUE READING