Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages.

  title={Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages.},
  author={Julia S. Kimbell and Rebecca A. Segal and Bahman Asgharian and Brian A. Wong and Jeffry D. Schroeter and Jeremy P Southall and Colin J Dickens and Geoff Brace and Frederick W Miller},
  journal={Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine},
  volume={20 1},
Many studies suggest limited effectiveness of spray devices for nasal drug delivery due primarily to high deposition and clearance at the front of the nose. Here, nasal spray behavior was studied using experimental measurements and a computational fluid dynamics model of the human nasal passages constructed from magnetic resonance imaging scans of a healthy adult male. Eighteen commercially available nasal sprays were analyzed for spray characteristics using laser diffraction, high-speed video… CONTINUE READING
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