Characterization of delayed rectifier K+ currents in rabbit coronary artery cells near resting membrane potential.

@article{Ishikawa1997CharacterizationOD,
  title={Characterization of delayed rectifier K+ currents in rabbit coronary artery cells near resting membrane potential.},
  author={Tomohisa Ishikawa and Delrae M. Eckman and Kathleen D. Keef},
  journal={Canadian journal of physiology and pharmacology},
  year={1997},
  volume={75 9},
  pages={1116-22}
}
Previous studies have suggested that delayed rectifier K+ (Kdr) channels contribute to the control of membrane potential in vascular smooth muscle. To explore this hypothesis further, we investigated the characteristics of Kdr channels in the negative voltage range in the rabbit coronary artery. The Kdr channel blocker 4-aminopyridine (1 mM) contracted intact vessels and depolarized them from -52 to -37 mV, suggesting that these channels significantly contribute to the maintenance of resting… CONTINUE READING

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