Characterization of cytokeratin 20 expression in pancreatic and colorectal cancer.

  title={Characterization of cytokeratin 20 expression in pancreatic and colorectal cancer.},
  author={St Wildi and Joerg Kleeff and Hidetoshi Maruyama and Christoph Andreas Maurer and Helmut Friess and Markus W. B{\"u}chler and Arthur D. Lander and Murray Korc},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={5 10},
Cytokeratin 20 belongs to the epithelial subgroup of the intermediate filament family. Because of its restricted range of expression in humans, it has become an important tool for detecting and identifying metastatic cancer cells by immunohistochemistry and by PCR analysis. Despite its widespread diagnostic use in colorectal cancer and occasional use in pancreatic cancer, little is known about the expression of CK 20 in these tumors in vivo. Therefore, in the present study we characterized CK… CONTINUE READING