Characterization of covalent adriamycin-DNA adducts.


Adriamycin is a popular antineoplastic agent whose ability to form covalent adducts with DNA has been correlated to cellular apoptosis (programmed cell death) in tumor models. We have isolated and purified this adduct formed under oxido-reductive (Fenton) conditions in Tris buffer. We show by homo- and heteronuclear NMR spectroscopy that the covalent… (More)


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@article{Zeman1998CharacterizationOC, title={Characterization of covalent adriamycin-DNA adducts.}, author={Suzanne Zeman and D. Ryan Phillips and D. M. Crothers}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1998}, volume={95 20}, pages={11561-5} }