Characterization of corneal pannus removed from patients with total limbal stem cell deficiency.

@article{Espana2004CharacterizationOC,
  title={Characterization of corneal pannus removed from patients with total limbal stem cell deficiency.},
  author={Edgar M. Espana and Mario A Di Pascuale and Hua He and Tetsuya Kawakita and V. Hemanth Kumar Raju and Chia-Yang Liu and Scheffer C. G. Tseng},
  journal={Investigative ophthalmology & visual science},
  year={2004},
  volume={45 9},
  pages={2961-6}
}
PURPOSE To determine the epithelial lineage of origin in corneal pannus tissue surgically removed from patients with total limbal stem cell (SC) deficiency. METHODS The lineage of origin of the entire conjunctivalized pannus removed from eight corneas with a diagnosis of total limbal SC deficiency was characterized by anti-keratin (K)-3 and anti-K19 monoclonal antibodies. The protein and mRNA of epithelial outgrowth from segments of five such pannus specimens were analyzed by Western blot and… CONTINUE READING

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