Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering.

@article{Ayello2006CharacterizationOC,
  title={Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering.},
  author={Janet Ayello and C Van de ven and Weiwei Fortino and Cheryl Wade-Harris and Prakash Satwani and Laxmi V. Baxi and Lynn L. Simpson and Warren Sanger and Diana Pickering and Joanne Kurtzberg and Mitchell S Cairo},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2006},
  volume={12 6},
  pages={608-22}
}
Cord blood (CB) natural killer (NK) and lymphokine-activated killer (LAK) cytotoxic cells are poorly characterized but might be used to treat minimal residual and/or recurrent malignant disease. Currently, there is no mechanism to use CB for adoptive cancer cellular immunotherapy after CB transplantation (CBT). Recognizing this as a deficiency, we hypothesized that CB aliquots could be engineered ex vivo for potential donor lymphocyte infusion after CBT. Cryopreserved CB aliquots were thawed… CONTINUE READING

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