Characterization of cord blood hematopoietic stem cells.

  title={Characterization of cord blood hematopoietic stem cells.},
  author={Fr{\'e}deric Mazurier and Monica Doedens and Olga I. Gan and John E Dick},
  journal={Annals of the New York Academy of Sciences},
A major problem hampering the development of effective stem cell-based therapies is the absence of a clear understanding of the composition of the hematopoietic stem cell (HSC) pool in humans and how ex vivo manipulation can differentially affect the various HSC classes. This paper will review recent advances in the use of the NOD/SCID xenotransplant assay to characterize the human stem cell compartment and to determine how ex vivo culture affects stem cells. Using lentivector-mediated clonal… CONTINUE READING