Characterization of compounds shed from the surface of human leukemic myeloblasts in vitro.

@article{Baker1982CharacterizationOC,
  title={Characterization of compounds shed from the surface of human leukemic myeloblasts in vitro.},
  author={Michael A. Baker and D. A. K. Roncari and Robert N. Taub and Thallachallour Mohanakumar and J. A. Falk and Steven Grant},
  journal={Blood},
  year={1982},
  volume={60 2},
  pages={412-9}
}
Human leukemic myeloblasts shed glycoproteins from the cell surface during short-term in vitro culture. Shed surface glycoproteins yield a characteristic profile when studied by gel chromatography, isoelectric focusing, immune precipitation, and polyacrylamide gel electrophoresis. Isolation of immunologically active material yields a compound to approximately 75,000--80,000 daltons, with an isoelectric point of 7.6 to 7.9. Various morphological subtypes of acute myelogenous leukemia shed these… CONTINUE READING