Characterization of collagen-like peptides containing interruptions in the repeating Gly-X-Y sequence.

@article{Long1993CharacterizationOC,
  title={Characterization of collagen-like peptides containing interruptions in the repeating Gly-X-Y sequence.},
  author={Catherine G. Long and Emory H. Braswell and Dan Zhu and J Apigo and J. M. Baum and Barbara Brodsky},
  journal={Biochemistry},
  year={1993},
  volume={32 43},
  pages={11688-95}
}
Glycine is found as every third residue along the entire length of triple helices in fibrillar collagens, but the triple-helix regions of nonfibrillar collagens and other proteins usually contain one or more interruptions in this repeating pattern. A set of four peptides was designed to model the effect of interruptions in the (Gly-X-Y)n repeating pattern on triple-helix formation, stability, and folding. Into the middle of the stable triple-helical peptide (Pro-Hyp-Gly)10, an interruption was… CONTINUE READING

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