Characterization of cimetidine transport in LLCPK1 cells.

  title={Characterization of cimetidine transport in LLCPK1 cells.},
  author={Reina Bendayan and Bryan Lo and Mel Silverman},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={5 1},
In this study, cimetidine uptake and its regulation by LLCPK1 monolayers were investigated. Uptake was temperature dependent with kinetic and specificity characteristics typical of a carrier-mediated mechanism. With cimetidine uptake in the presence of an excess concentration of the potent inhibitor quinidine as a measure of nonspecific transport, the estimated kinetic parameters for cimetidine uptake at 37 degrees C under steady-state conditions are Km = 32.3 +/- 6.4 microM and Vmax = 20.2… CONTINUE READING


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pH in cultured proximal tubular cells

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