Characterization of cholecystokinin from the human brain.

  title={Characterization of cholecystokinin from the human brain.},
  author={Laurence J. Miller and Ian Jardine and E M Weissman and Vay Liang W. Go and David G. Speicher},
  journal={Journal of neurochemistry},
  volume={43 3},
Human forms of cholecystokinin have not previously been characterized chemically. In this study, we have extracted and purified the predominant molecular form of cholecystokinin present in human cerebral cortex. The peptide was characterized by amino acid analysis, automated peptide sequencing, and fast atom bombardment mass spectrometry. It appears to be identical to porcine cholecystokinin-octapeptide, with the sequence of Asp-Tyr(SO3)-Met-Gly-Trp-Met-Asp-Phe(NH2). This structural identity is… CONTINUE READING