Characterization of chloramphenicol palmitate drug polymorphs by Raman mapping with multivariate image segmentation using a spatial directed agglomeration clustering method.

@article{Lin2006CharacterizationOC,
  title={Characterization of chloramphenicol palmitate drug polymorphs by Raman mapping with multivariate image segmentation using a spatial directed agglomeration clustering method.},
  author={Wei-Qi Lin and Jian-Hui Jiang and Haifeng Yang and Yukihiro Ozaki and Guo-Li Shen and Ruqin Yu},
  journal={Analytical chemistry},
  year={2006},
  volume={78 17},
  pages={6003-11}
}
Chemical imaging analysis holds great potential in probing the chemical heterogeneity of samples with high spatial resolution and molecular specificity. This paper demonstrates the implementation of Raman mapping for microscopic characterization of tablets containing chloramphenicol palmitate polymorphs with the aid of a new multivariate image segmentation approach based on spatial directed agglomeration clustering. This approach performs the agglomeration clustering by stepwise merging the… CONTINUE READING

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