Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes.

@article{Farkas2005CharacterizationOC,
  title={Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes.},
  author={Dora Farkas and Steven R Tannenbaum},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={85 2},
  pages={927-34}
}
It has been shown that hepatocytes cultured in a collagen sandwich configuration maintain cell viability, morphology, and drug metabolizing activities for several weeks. The purpose of this study was to characterize chemically induced general toxicity in this system by exposing hepatocytes to eight different hepatotoxic compounds. Cell function and viability was measured by analyzing the secretions of urea and albumin and the release of lactate dehydrogenase. Significant decreases in urea and… CONTINUE READING
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