Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models

@inproceedings{Sun2013CharacterizationOC,
  title={Characterization of cellular uptake and toxicity of aminosilane-coated iron oxide nanoparticles with different charges in central nervous system-relevant cell culture models},
  author={Zhizhi Sun and Vinith Yathindranath and Matthew Worden and James A. Thliveris and Stephanie K Chu and Fiona E Parkinson and Torsten Hegmann and Donald W Miller},
  booktitle={International journal of nanomedicine},
  year={2013}
}
BACKGROUND Aminosilane-coated iron oxide nanoparticles (AmS-IONPs) have been widely used in constructing complex and multifunctional drug delivery systems. However, the biocompatibility and uptake characteristics of AmS-IONPs in central nervous system (CNS)-relevant cells are unknown. The purpose of this study was to determine the effect of surface charge and magnetic field on toxicity and uptake of AmS-IONPs in CNS-relevant cell types. METHODS The toxicity and uptake profile of positively… CONTINUE READING

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