Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples.

@article{Pearce2005CharacterizationOC,
  title={Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples.},
  author={Daniel J. Pearce and David Christopher Taussig and Catherine D Simpson and Kirsty Allen and Ama Z. S. Rohatiner and T. Andrew Lister and Dominique Bonnet},
  journal={Stem cells},
  year={2005},
  volume={23 6},
  pages={752-60}
}
Aldehyde dehydrogenase (ALDH) is a cytosolic enzyme that is responsible for the oxidation of intracellular aldehydes. Elevated levels of ALDH have been demonstrated in murine and human progenitor cells compared with other hematopoietic cells, and this is thought to be important in chemoresistance. A method for the assessment of ALDH activity in viable cells recently has been developed and made commercially available in a kit format. In this study, we confirmed the use of the ALDH substrate kit… CONTINUE READING

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