Characterization of cells from human giant cell tumors of bone.

  title={Characterization of cells from human giant cell tumors of bone.},
  author={Steven Robert Goldring and Alan L. Schiller and Henry J. Mankin and Jean-Michel Dayer and Stephen M. Krane},
  journal={Clinical orthopaedics and related research},
In vitro cell culture techniques were used to identify and characterize the individual cell types present in human giant cell tumors of bone. Three major cell types were identified based on morphologic characteristics, patterns of specific cell surface antigens, presence of receptors for hormones, and cell products. One population consisted of mononuclear cells that expressed monocyte-macrophage markers. These cells lacked receptors for skeletal hormones and did not persist in culture. Distinct… CONTINUE READING