Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells.

@article{Yamazaki1998CharacterizationOC,
  title={Characterization of cell cycle checkpoint responses after ionizing radiation in Nijmegen breakage syndrome cells.},
  author={Vikky Yamazaki and Raphael Wegner and Cordula U. Kirchgessner},
  journal={Cancer research},
  year={1998},
  volume={58 11},
  pages={
          2316-22
        }
}
Nijmegen breakage syndrome (NBS), which in the past also has been classified as a variant of ataxia telangiectasia (AT), is characterized by cancer proneness and extreme sensitivity to ionizing radiation. We investigated the DNA damage responses of four independent primary NBS fibroblast cell lines. Following a low dose of ionizing radiation, p53 is mostly induced with slower kinetics and shows more transient induction in NBS fibroblasts. Nonetheless, this damage-induced protein appears… CONTINUE READING

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