Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses.

@article{Davidsen2005CharacterizationOC,
  title={Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6'-dibehenate)-a novel adjuvant inducing both strong CMI and antibody responses.},
  author={Jesper Davidsen and Ida Rosenkrands and Dennis E. Christensen and Anil Vangala and Daniel Kirby and Yvonne Perrie and Else Marie Agger and Peter Hvilsh\oj Andersen},
  journal={Biochimica et biophysica acta},
  year={2005},
  volume={1718 1-2},
  pages={22-31}
}
Incorporation of the glycolipid trehalose 6,6'-dibehenate (TDB) into cationic liposomes composed of the quaternary ammonium compound dimethyldioctadecylammonium (DDA) produce an adjuvant system which induces a powerful cell-mediated immune response and a strong antibody response, desirable for a high number of disease targets. We have used differential scanning calorimetry (DSC) to investigate the effect of TDB on the gel-fluid phase transition of DDA liposomes and to demonstrate that TDB is… CONTINUE READING

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