Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart.

@article{Angstadt2011CharacterizationOC,
  title={Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart.},
  author={Andrea Y Angstadt and Alison A. Motsinger-Reif and Rachael Thomas and William C. Kisseberth and C Guillermo Couto and Dawn L. Duval and Dahlia M. Nielsen and Jaime F Modiano and Matthew Breen},
  journal={Genes, chromosomes & cancer},
  year={2011},
  volume={50 11},
  pages={859-74}
}
Osteosarcoma (OS) is the most commonly diagnosed malignant bone tumor in humans and dogs, characterized in both species by extremely complex karyotypes exhibiting high frequencies of genomic imbalance. Evaluation of genomic signatures in human OS using array comparative genomic hybridization (aCGH) has assisted in uncovering genetic mechanisms that result in disease phenotype. Previous low-resolution (10-20 Mb) aCGH analysis of canine OS identified a wide range of recurrent DNA copy number… CONTINUE READING